Article: Increasing SK2 Channel Activity Impairs Associative Learning.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) McKay BM; Oh MM; Galvez R; Burgdorf J; Kroes RA; Weiss C; Adelman JP; Moskal JR; Disterhoft JF J. Neurophysiol., 2012
aCSF | NS309 | |
---|---|---|
Vrest (mV) | -65.1 ± 0.9 | -64.8 ± 1.2 |
Input resistance (MΩ) | 88.6 ± 2.3 | 83.5 ± 4.3 |
Sag (mV) | 3.22 ± 0.29 | 3.46 ± 0.42 |
sAHP (mV) | -1.77 ± 0.25 | -1.61 ± 0.39 |
AP thresh (mV) | -50.1 ± 1.5 | -51.5 ± 1.9 |
AP height (mV) | 94.2 ± 4.3 | 94.1 ± 2.7 |
AP half-width (ms) | 1.14 ± 0.06 | 1.05 ± 0.06 |
Values are means ± SE. Vrest is the resting membrane potential immediately after breaking into the cell. Input resistance is calculated as the slope of the current-voltage (I-V) curve. Sag is the difference between the peak and steady-state hyperpolarization in response to a -250 pA, 800-ms current injection. The sAHP was measured 1 s after the end of the last action potential in a five-spike train. Action potentials were elicited by a long depolarizing pulse sufficient to evoke a single action potential in 100 ms. Threshold was measured where the first derivative of the upslope of the trace equals 20 mV/ms. Height is the difference between the baseline and maximal depolarization. Half-width is width of the action potential at the midpoint between the maximal depolarization and the threshold. N = 9.